Lung Carcinoma
Lung carcinoma being the number 1 killer among all the cancer in both gender worldwide.
I think it is due to the limitation of specific and sensitive diagnostic tool for diagnosis and often the manifestation of the clinical presentation will indicate a rather late stage of the disease.
We study lung carcinoma by dividing them into 2 groups: small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC).
)SCLC (oats cell Ca
-15% of lung Ca
-poorly differentiated form neuroendocrine cell( Kulchisky cell)
-not surgical resectable, Rx by chemotherapy
-associated with 4A:
ACTH
ADH
Antibodies towards the presynaptic calcium channels ( Eaton-Lambert syndrome: mostly affect proximal muscle)
Amplification of myc genes
NSCLC is divided into adenocarcinoma, squamous cell carcinoma and large cell carcinoma
Adenocarcinoma: (most common)*
-40% of lung ca
- most common in female and non-smoker ( if you see this during exam, it gives the answer away!!!)
-periphery located
-associated with finger clubbing
Bronchioloalveolar (subtyoe of adenocarcinoma)
-good prognosis
-CXR: similar to pneumonia, hazy-liked
Squamous cell carcinoma
-30% of lung Ca
- most common smoker tumour
- predominant centrally located
- may cause cavitation and hypercalcemia ( due to PTH secretion)
Large cell carcinoma
-10% of lung Ca
-poor prognosis
Bronchial carcinoid
-5%
-non-smoker related
-good prognosis
-may have carcinoid syndrome( * maybe I will have a separate post to explain this) causing wheezing, flushing and diarrhoea.
Let's not forget lung is the favourite place for cancer metastasised either by lymphatic or directly.
Male: commonly from colon Ca
Female: commonly from breast Ca
Lung Ca itself commonly metastasis to liver, brain, adrenal and bone
If any of you who came across the blog and read this post. Would you mind sharing some of the good articles or journals regarding the current Lung Carcinoma diagnosis with me??? Thanks in advance! Have a good day :)
I think it is due to the limitation of specific and sensitive diagnostic tool for diagnosis and often the manifestation of the clinical presentation will indicate a rather late stage of the disease.
We study lung carcinoma by dividing them into 2 groups: small cell lung carcinoma (SCLC) and non-small cell lung carcinoma (NSCLC).
)SCLC (oats cell Ca
-15% of lung Ca
-poorly differentiated form neuroendocrine cell( Kulchisky cell)
-not surgical resectable, Rx by chemotherapy
-associated with 4A:
ACTH
ADH
Antibodies towards the presynaptic calcium channels ( Eaton-Lambert syndrome: mostly affect proximal muscle)
Amplification of myc genes
NSCLC is divided into adenocarcinoma, squamous cell carcinoma and large cell carcinoma
Adenocarcinoma: (most common)*
-40% of lung ca
- most common in female and non-smoker ( if you see this during exam, it gives the answer away!!!)
-periphery located
-associated with finger clubbing
Bronchioloalveolar (subtyoe of adenocarcinoma)
-good prognosis
-CXR: similar to pneumonia, hazy-liked
Squamous cell carcinoma
-30% of lung Ca
- most common smoker tumour
- predominant centrally located
- may cause cavitation and hypercalcemia ( due to PTH secretion)
Large cell carcinoma
-10% of lung Ca
-poor prognosis
Bronchial carcinoid
-5%
-non-smoker related
-good prognosis
-may have carcinoid syndrome( * maybe I will have a separate post to explain this) causing wheezing, flushing and diarrhoea.
Let's not forget lung is the favourite place for cancer metastasised either by lymphatic or directly.
Male: commonly from colon Ca
Female: commonly from breast Ca
Lung Ca itself commonly metastasis to liver, brain, adrenal and bone
If any of you who came across the blog and read this post. Would you mind sharing some of the good articles or journals regarding the current Lung Carcinoma diagnosis with me??? Thanks in advance! Have a good day :)
Comments
Post a Comment